What Is Dry Heat Sterilization
Dry heat sterilization refers to items in the dry heat sterilizer, sterilization tunnel and other autoclave manufacturer equipment, the use of dry and hot air to kill the microbes or eliminate pyrogen approach. But not suitable for high-temperature sterilization with moist heat sterilization sterilization items, such as glassware, metal containers, fiber products, solid reagents, liquid paraffin etc Act can be sterilized.
Dry heat sterilization conditions is generally 160 ~ 170 ℃ × 120min above, 170 ~ 180 ℃ × 60min or more, or 250 ℃ × 45min or more, may also have other temperature and time parameters. In short, should ensure that their products after sterilization SAL ≤ 10-6. After the dry heat over the killing of products SAL should ≤ 10-12, this time items generally determined prior to sterilization without microbial contamination. 250 ℃ 45min dry heat sterilization can also be removed by aseptic packaging containers and related steam sterilizer exporter equipment in the production of filling pyrogenic substances.
When using dry heat sterilization, should be sterilized items are packed and loaded the appropriate way to ensure the effectiveness and uniformity of sterilization.
Dry heat sterilization and moist heat sterilization validation same test should be carried out heat distribution, heat penetration test, validate biological indicator inactivation of bacterial endotoxin test or validation tests. To confirm the sterilizer temperature distribution in compliance with the standards set, to determine the coldest point, confirm the coldest point standard sterilization time (FH) can reach the set standards and achieve SAL requirements. Commonly used as a biological indicator Bacillus subtilis spores (Spores of Bacillus subtilis). Inactivation of bacterial endotoxin test in addition to verification test is to prove the effectiveness of pyrogenic process. Stay tuned on http://www.autoclavesale.com/ .Will generally not be less than 1,000 units of the bacterial toxin to be added to the items of pyrogen, the pyrogen-proof inner process can go down at least three pairs of endotoxin unit. Bacterial endotoxin test to verify inactivation of bacterial endotoxin used generally within Escherichia coli endotoxin (Escherichia coli endoxin). When validated, the general maximum loading mode.